Well, the answer is yes. Soon after I posted above, I remembered I had another siren amp I could borrow transistors from. When I swapped them into the faulty amp, it worked as it should.
The question I still have-
Is a bad transistor typically a primary problem or is it typically just a symptom of a bigger problem? I.e. is the siren likely good to go now that the bad transistor has been replaced or did some other problem cause the original transistor to fail, and will thus soon cause the replacement to fail as well?
Anything else I'm not thinking about? I see in manual you are supposed to chevk the symmetry of the output waveform after replacing a transistor. I don't have an oscillascope, so can't do that. No idea if that's a big issue or not.