as far as running the wires,there is a port with a rubber grommet on the driver side firewall.from the engine compartment.look about 2-3 inches below the wiper cowl.it is sometime hidden by wires,etc. as far as running from the taillights,is it a standard cab or extended cab.if you remove the trim and expose the wire channel and or pull back the carpet there will be another entry port in either the channel and or under the backseat/lower back wall of the truck sealed with a rubber grommet. they are not hard to install strobes on buts its been awhile since i did my old dakota.as far as placement dont install the strobe tube to close to the headlight bulb due to heat from the strobe tube or the head light bulb and dont mount it too close to the front of the headlight othersie it will melt the lense of the headlight,already made that mistake, hope this helps
also it helps to run the cables along the main wire bundle under the truck to your entry point,it is easier to secure them and looks neater under the veh if you care
Tom